2. REMOVING EXCESS ESTROGEN
High levels of beta-glucuronide increase the number of estrogen receptors. This means estrogen that would have been excreted is now able to bind to more receptors. This can cause increased tissue growth, inability to lose fat, and even man boobs.
Estrogen dominance is one of the leading causes of infertility, mood imbalances, and other health problems in women. One of the most common treatments for high estrogen levels in a drug called tamoxifen. Tamoxifen has numerous side effects including stroke, blood clots, uterine cancer, and cataracts.
New research shows that CDG could be just as effective as Tamoxifen in treating estrogen dominance. CDG allows excess estrogen to be passed out of the body. A review in 2003 said calcium-d-glucarate could be as effective in preventing cancer as Tamoxifen.
In one study, calcium-d-glucarate was able to reduce the number of estrogen receptors by 48 percent. It’s also been shown to lower serum estrogen levels by 23 percent.
High estrogen is also a problem for men. Whether your a man or woman, calcium-d-glucarate will help maintain proper hormone balance.
3. DECREASE LDL CHOLESTEROL
Despite the numerous health effects of a paleo diet, one of the mysterious negative effects seems to be elevated LDL cholesterol. Paul Jaminet wrote an excellent post on this topic where numerous people said they experienced high LDL levels.
Not only is total cholesterol increased, but it’s LDL cholesterol. This isn’t necessarily a bad thing as long as it’s type-A LDL (large, puffy, non-atherogenic). However, since being Bulletproof means doing everything possible to ensure optimal health, this is something that needs to be dealt with. High LDL isn’t necessarily the problem. It’s a sign of tissue damage or toxins which is the problem.
When cells are stressed or damaged, they need cholesterol for repair. As Dr. Jaminet also pointed out, high LDL levels are needed to repair damaged tissue.
The body sends LDL molecules to supply various parts of the body with cholesterol and fats. Limited blood flow is one form of stress. Calcium-d-glucarate is metabolized into glucaric salts. Glucaric salts reduces beta-glucuronidase production by gut bacteria. Reducing beta-glucuronidase enhances enterohepatic (liver) circulation which reduces cholesterol synthesis. This causes lower cholesterol levels.
In rats, CDG lowers total cholesterol by 12-15 percent, and LDL cholesterol by 30-35 percent. In humans, CDG lowers cholesterol by 12 percent, and LDL cholesterol by 28 percent. It can also lower triglycerides up to 43 percent.
CDG is not arbitrarily playing with cholesterol numbers like statins. It decreases stress on the liver which lowers your need for cholesterol, especially LDL cholesterol.
4. GREAT FOR HIGH PROTEIN DIETS
Humans are meant to eat large amounts of protein and fat. Our livers and kidney efficiently process proteins and are able to remove harmful byproducts like ammonia. However, humans can only handle so many toxins. The human body is involved fending off xenoestrogens, air pollutants, chronic infections, and mycotoxins. This leaves very little room for dealing with the metabolites of protein. Our modern world is so polluted, that humans don’t always have the necessary means to fend off natural byproducts of a healthy metabolism. If you’re consuming a high protein diet (25-35 percent), you should consider supplementing with calcium-d-glucarate.
DOSAGE AND POSSIBLE SIDE EFFECTS
Recommended dose: A normal detox dose is 500-1000 mg. People with high estrogen may benefit from taking as much as 3000-4500 mg a day – ask your doctor before adding any supplement to your regimen.
CDG can interact with alcohol and some drugs that act on the liver, like statins. WebMD has the full list of possible interactions listed here.
Time taken: Doesn’t really matter.
By taking this one supplement, you can remove toxins, ensure healthy liver function, and lower your LDL and total cholesterol. Calcium-d-glucarate is one of the safest, most effective biohacks available.
For more supplements I recommend for nearly everyone, check out this post.